What concentration of heparin is typically used to lock hemodialysis lines?

The typical concentration of heparin used to lock hemodialysis lines is in the range of 3000 to 5000 units per lumen. This concentration is effective in preventing clot formation within the dialysis lines without posing excessive risk for bleeding or complications associated with higher doses.

Using this concentration strikes a balance between ensuring adequate anticoagulation in the lines while minimizing the potential for systemic absorption of heparin, which can lead to adverse effects. The adoption of this range is also supported by clinical guidelines and practices based on the pharmacokinetics of heparin, which allow it to exert its anticoagulant effects while still being safely managed within the hemodialysis setting.

Concentrations above or below this range may compromise the efficacy of the lock solution or increase risks, making the use of 3000 to 5000 units per lumen a well-established standard in clinical practice for maintaining hemodialysis access.