Which vein is associated with the highest risk for central line-associated bloodstream infections (CLABSI) due to its anatomical location?

The femoral vein is associated with the highest risk for central line-associated bloodstream infections (CLABSI) due to its anatomical location, which is typically more exposed to contamination in the groin area where it branches from the iliac veins. This region is more difficult to keep sterile than other sites, increasing the likelihood of infection. Additionally, positioning a central line in the femoral vein may also subject the line to potential complications from external factors, such as movement or proximity to urinary catheters, which can also increase infection risk.

This is in contrast to other veins mentioned, such as the brachial, internal jugular, and axillary veins, which are located in areas that can be more easily managed for sterility and typically have a lower incidence of CLABSI when lines are inserted and maintained properly. Therefore, while all vascular access sites carry some risk for infections, the femoral vein stands out as a more considerable risk due to its anatomical and situational factors that contribute to increased infection rates.